Regional cerebral blood flow alterations in obstructive sleep apnea
نویسندگان
چکیده
منابع مشابه
Cerebral blood flow and cognitive function in obstructive sleep apnea syndrome.
Neuropsychological deficits are among the main symptoms of obstructive sleep apnea syndrome (OSAS), which could be related to impaired cerebral blood flow (CBF). We conducted a study in 20 subjects tested in our Sleep Laboratory, to assess regional CBF and cognitive function in OSAS. Our measurements included technetium-99m hexamethylamino propylenamine oxime brain perfusion scintigraphy in wak...
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STUDY OBJECTIVES Children with obstructive sleep apnea syndrome (OSAS) often experience periods of hypercapnia during sleep, a potent stimulator of cerebral blood flow (CBF). Considering this hypercapnia exposure during sleep, it is possible that children with OSAS have abnormal CBF responses to hypercapnia even during wakefulness. Therefore, we hypothesized that children with OSAS have blunted...
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Obstructive sleep apnea (OSA) increases the risk of stroke independent of known vascular and metabolic risk factors. Although patients with OSA have higher prevalence of hypertension and evidence of hypercoagulability, the mechanism of this increased risk is unknown. Obstructive apnea events are associated with surges in blood pressure, hypercapnia, and fluctuations in cerebral blood flow. Thes...
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We have investigated cerebral blood flow velocity (CBVF) in 14 patients with marked obstructive sleep apnea syndrome using transcranial Doppler ultrasonography during sleep. The CBFV increased during apnea, with a mean acceleration of 0.9 cm/s2, followed by a rapid decrease during snoring. The same effect was obtained by voluntary apnea in healthy subjects, showing a smaller acceleration rate (...
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Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected. We assessed the presence of neuronal injury, measured as regional grey matter volume, in 16 OSA children (8 male, 8.1 ± 2.2 years, AHI:11.1 ± 5.9 events/hr), and 200 control subjects (84 male, 8....
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2013
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2013.09.033